8-Chloro-3-iodoimidazo[1,2-a]pyrazine synthesis
- Product Name:8-Chloro-3-iodoimidazo[1,2-a]pyrazine
- CAS Number:1049677-32-8
- Molecular formula:C6H3ClIN3
- Molecular Weight:279.47
![8-Chloro-3-iodoimidazo[1,2-a]pyrazine](/NewsImg/2023-10-16/6383305249051059107688690.jpg "8-Chloro-3-iodoimidazo[1,2-a]pyrazine")
![8-Chloro-imidazo[1,2-a]pyrazine](/CAS/GIF/69214-33-1.gif)
69214-33-1
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Yield:1049677-32-8 75.8%
Reaction Conditions:
with N-iodo-succinimide in N,N-dimethyl-formamide at 20; for 48 h;Inert atmosphere;
Steps:
1.1 8-chloro-3-iodoimidazo[1,2-a]pyrazine
8-chloroimidazo[1,2-a]pyrazine (5.2 g, 33.9 mmol, Eq: 1) and NIS (8 g, 35.6 mmol, Eq: 1.05) were combined with DMF (34 ml). The reaction mixture was stirred at RT for 48 h. Water was added to the suspension and the solid was filtered, washed with water and MeOH and dried under HV to afford the title compound (7.17 g, 25.6 mmol, 75.8% yield) as an off-white solid. MS (ESI, m/z): 280.0 [M+H]+.
References:
WO2021/249896,2021,A1 Location in patent:Page/Page column 51-53
105076-76-4
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1049677-32-8
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