ChemicalBook CAS DataBase List 8-Amino-2H-1,4-benzoxazin-3(4H)-one

8-Amino-2H-1,4-benzoxazin-3(4H)-one synthesis

7synthesis methods

Product Name:8-Amino-2H-1,4-benzoxazin-3(4H)-one
CAS Number:321126-82-3
Molecular formula:C8H8N2O2
Molecular Weight:164.16

870064-73-6 Synthesis

6-CHLORO-8-NITRO-4H-BENZO[1,4]OXAZIN-3-ONE

870064-73-6
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$85.00/100mg

321126-82-3
28 suppliers
$80.00/250 mg

Yield: 83%

Reaction Conditions:

with hydrogen;palladium on activated charcoal in ethanol at 50; for 4 h;

Steps:

38
Intermediate 58:[0208] Intermediate 57 (326 mg, 1.4 mmol) was dissolved in EtOH, then Pd/C (0.03 g) was added. The mixture was hydrogenated under H₂ for 4 h at 50°C. The reaction mixture was filtered over Hyflo and the filtrate was concentrated in vacuo to give 8-amino-2H- benzo[b][l,4]oxazin-3(4H)-one (intermediate 58) (83%) as a brown solid, which was used in the next step without any further purification.

References:

THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;JIN, Jian;ROTH, Bryan;FRYE, Stephen WO2012/3418, 2012, A2 Location in patent:Page/Page column 94

1042973-67-0 Synthesis