3-Isoxazolecarboxylic acid, 5-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-, ethyl ester synthesis

8synthesis methods

Product Name:3-Isoxazolecarboxylic acid, 5-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-, ethyl ester
CAS Number:747414-20-6
Molecular formula:C29H29NO5
Molecular Weight:471.54

1133784-21-0
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3-Isoxazolecarboxylic acid, 5-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-, ethyl ester

747414-20-6
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Yield:747414-20-6 91%

Reaction Conditions:

with hydroxylamine hydrochloride in ethanol; for 4 h;Heating;

References:

Brough, Paul A.;Aherne, Wynne;Barril, Xavier;Borgognoni, Jenifer;Boxall, Kathy;Cansfield, Julie E.;Cheung, Kwai-Ming J.;Collins, Ian;Davies, Nicholas G. M.;Drysdale, Martin J.;Dymock, Brian;Eccles, Suzanne A.;Finch, Harry;Fink, Alexandra;Hayes, Angela;Howes, Robert;Hubbard, Roderick E.;James, Karen;Jordan, Allan M.;Lockie, Andrea;Martins, Vanessa;Massey, Andrew;Matthews, Thomas P.;McDonald, Edward;Northfield, Christopher J.;Pearl, Laurence H.;Prodromou, Chrisostomos;Ray, Stuart;Raynaud, Florence I.;Roughley, Stephen D.;Sharp, Swee Y.;Surgenor, Allan;Walmsley, D. Lee;Webb, Paul;Wood, Mike;Workman, Paul;Wright, Lisa [Journal of Medicinal Chemistry,2008,vol. 51,# 2,p. 196 - 218]

747414-17-1 Synthesis