3-(5-OXO-3-THIOXO-2,3,4,5-TETRAHYDRO-[1,2,4]TRIAZIN-6-YL)-PROPIONIC ACID synthesis
1synthesis methods
- Product Name:3-(5-OXO-3-THIOXO-2,3,4,5-TETRAHYDRO-[1,2,4]TRIAZIN-6-YL)-PROPIONIC ACID
- CAS Number:7338-78-5
- Molecular formula:C6H7N3O3S
- Molecular Weight:201.2
Yield:7338-78-5 48%
Reaction Conditions:
Stage #1: diethyl 2-ketoglutarate;thiosemicarbazidewith hydrogenchloride in ethanol;water at 20; for 18 h;Acidic conditions;
Stage #2: with potassium hydroxide in ethanol;water; for 2 h;Heating / reflux;Alkaline conditions;
Stage #3: with hydrogenchloride in ethanol;water; pH=1;Acidic conditions;
References:
WO2005/3118,2005,A1 Location in patent:Page/Page column 37-38