1H-Isoindole-1,3(2H)-dione, 2-[[(5S)-3-(3-fluoro-4-iodophenyl)-2-oxo-5-oxazolidinyl]Methyl]- synthesis
- Product Name:1H-Isoindole-1,3(2H)-dione, 2-[[(5S)-3-(3-fluoro-4-iodophenyl)-2-oxo-5-oxazolidinyl]Methyl]-
- CAS Number:724793-80-0
- Molecular formula:C18H12FIN2O4
- Molecular Weight:466.2
Yield:724793-80-0 93%
Reaction Conditions:
in N,N-dimethyl-formamide at 70; for 4 h;
Steps:
General procedure-4: Formation of A5 methyl phthalimide analogs
General procedure: Compound 4 (1 mmol) was dissolved in anhydrous DMF (5 mL), then potassium phthalimide (1.2 equiv.) was added, and the resulting reaction mixture was warmed to 70 °C and stirred for 4 hrs. Then it was cooled to room temperature before DDW (20 mL) was added. The formed precipitate was collected by filtration, washed with DDW (2×5 mL) and dried under vacuum.
References:
Spaulding, Andrew;Takrouri, Khuloud;Mahalingam, Pornachandran;Cleary, Dillon C.;Cooper, Harold D.;Zucchi, Paola;Tear, Westley;Koleva, Bilyana;Beuning, Penny J.;Hirsch, Elizabeth B.;Aggen, James B. [Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,# 23,p. 5310 - 5321] Location in patent:supporting information
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