3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine synthesis
- Product Name:3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine
- CAS Number:69304-38-7
- Molecular formula:C21H38N2O7Si2
- Molecular Weight:486.71
69304-37-6
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58-96-8
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69304-38-7
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Yield: 100%
Reaction Conditions:
with pyridine at 20; for 16 h;Cooling with ice;
Steps:
58 Example 58
To an ice cooled solution of 82-1 (50 g, 204.9 mmol) in dry Py (400 mL) was added TIPDSCl (70.78 g, 225.4 mmol) dropwise. The mixture was stirred at R.T. for 16 h, and then concentrated at low pressure. The residue was purified by chromatography using 20% EA in PE to generate 82-2 (111.5 g, 100%) as a white solid.
References:
ALIOS BIOPHARMA, INC.;Beigelman, Leonid;Wang, Guangyi;Smith, David Bernard US2014/179627, 2014, A1 Location in patent:Paragraph 0565
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69304-38-7
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69304-38-7
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18043-71-5
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69304-38-7
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$19.00/250mg
1000210-73-0
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69304-38-7
57 suppliers
$19.00/250mg