6,7-Dibromo-8-nitro-2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid synthesis
- Product Name:6,7-Dibromo-8-nitro-2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid
- CAS Number:66411-18-5
- Molecular formula:C9H5Br2NO6
- Molecular Weight:382.95
![6,7-Dibromo-2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid](/CAS/GIF/66411-17-4.gif)
66411-17-4
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66411-18-5
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Yield:66411-18-5 93%
Reaction Conditions:
with sulfuric acid;nitric acid;acetic acid at 0 - 25; for 2 h;Temperature;
Steps:
2 Step 2 - 6,7-Dibromo-5-nitro-2,3-dihydro-1,4-benzodioxine-8-carboxylic acid
To a solution of 6,7-dibromo-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid (1.80 g, 5.33 mmol) in AcOH (27 mL) was added H2SO4 (18 mL) at 0 °C. Then HNO3 (671 mg, 10.6 mmol) was added dropwise at 0 °C. Then the mixture was warmed to 25 °C for 2 hours. On completion, the mixture was concentrated to give the title compound (1.90 g, 93% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 7.03 (d, J = 8.4 Hz, 1H), 6.01 (dd, J = 2.4, 8.0 Hz, 2H).
References:
WO2021/188948,2021,A1 Location in patent:Paragraph 001773; 001776-001777; 001916; 001919-001920
4442-53-9
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66411-18-5
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