ChemicalBook CAS DataBase List (3aS,8aR)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

(3aS,8aR)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole synthesis

9synthesis methods

Product Name:(3aS,8aR)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
CAS Number:65166-97-4
Molecular formula:C14H20N2O
Molecular Weight:232.32

50-00-0 Synthesis

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Pyrrolo[2,3-b]indole, 1,2,3,3a,8,8a-hexahydro-5-methoxy-3a,8-dimethyl-, (3aS,8aR)-

104069-11-6
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(3aS,8aR)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

65166-97-4
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Yield:65166-97-4 92%

Reaction Conditions:

Stage #1: formaldehyd;(3aS,8aR)-5-methoxy-3a,8-dimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole in methanol;water at 0; for 0.0833333 h;Inert atmosphere;
Stage #2: with sodium tris(acetoxy)borohydride in methanol;water at 20; for 1.5 h;Inert atmosphere;

References:

Nakao, Yoshiaki;Ebata, Shiro;Yada, Akira;Hiyama, Tamejiro;Ikawa, Masashi;Ogoshi, Sensuke [Journal of the American Chemical Society,2008,vol. 130,p. 12874 - 12875] Location in patent:supporting information; experimental part

593-51-1 Synthesis