3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline synthesis
- Product Name:3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
- CAS Number:641571-11-1
- Molecular formula:C11H10F3N3
- Molecular Weight:241.21
822-36-6
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Yield:641571-11-1 96.18%
Reaction Conditions:
with copper(l) iodide;(+)-D-glucosamine hydrochloride;caesium carbonate in water;dimethyl sulfoxide at 90; for 12 h;Temperature;Concentration;
Steps:
2
In a reaction vessel, 24 g (0.1 mol) of 3-bromo-5-trifluoromethylaniline,8.2 g (0.1 mol) of 4-methylimidazole,58.7 g (0.18 mol) Cs2CO3,0.95 g (0.005 mol) CuI, 1.1 g (0.005 mol) D-glucosamine hydrochloride,Then 60 mL DMSO and 80 mL water were added,Stirring to dissolve, the reaction temperature was controlled at 90 ,The reaction was continued for 12 hours. After the reaction was completed, 120 mL of ethyl acetate was added,After centrifugation to take the supernatant,Concentration and drying gave 3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline.The HPLC purity was 98.66% and the yield was 96.18%
References:
CN105949128,2016,A Location in patent:Paragraph 0019-0020; 0021-0022; 0023-0024
![1H-IMidazole, 4-Methyl-1-[3-nitro-5-(trifluoroMethyl)phenyl]-](/CAS/GIF/916975-92-3.gif)
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![Acetamide, N-[3-amino-5-(trifluoromethyl)phenyl]-](/CAS/20210305/GIF/455279-96-6.gif)
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