ChemicalBook CAS DataBase List 6-(TRIFLUOROMETHYL)URACIL

6-(TRIFLUOROMETHYL)URACIL synthesis

6synthesis methods

Product Name:6-(TRIFLUOROMETHYL)URACIL
CAS Number:672-45-7
Molecular formula:C5H3F3N2O2
Molecular Weight:180.08

372-31-6 Synthesis

372-31-6
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$5.00/10g

57-13-6 Synthesis

57-13-6
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$5.00/5g

672-45-7
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$14.00/1g

Yield: 22%

Reaction Conditions:

with sodium ethanolate in ethanol at 20 - 90; for 24 h;Inert atmosphere;

Steps:

11 Synthesis of
To a stirred solution of ethyl 4.4,44rifluoro-3-oxobutanoate 101 (3 g. 1 &30 nim-ol) in ethin.iol (30 mL) under argon atmosphere were added urea 102- (978 mg, 16.30 mmol) and freshly prepared sodium ethoxide (750 mg of Na in 30 mL of EtOH) at Pt; the mixture was heated to 90 °C and stirred for 24 h. The reaction was monitored by TIE; after completion of the reaction, the volati Ic-s were removed in vacua, diluted with water (25 mL), acidified with 1 N SC1 UO niL) and extracted with EtOAc (2 x 40 niL). The comb med organic extracts were dried over sodium sulfate, filtered and concentrated in vacua to afford compound 103 (650 mg, 22%) as a white solid. TL-C: 5% CH3OR CK2CI2 (1?,: 0.3); ‘H-NMR (DMSO-%, 500 MHz): 6 1107 (s. 114), i1.54(s. iS). 6.07 (s, 1H

References:

INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION;ZLOTNICK, Adam;LI, Lichun;TURNER, William Jr.;FRANCIS, Samson WO2015/57945, 2015, A1 Location in patent:Paragraph 00121