6-nitrocoumarin synthesis
- Product Name:6-nitrocoumarin
- CAS Number:2725-81-7
- Molecular formula:C9H5NO4
- Molecular Weight:191.14
91-64-5
685 suppliers
$5.00/100mg
2725-81-7
129 suppliers
$36.00/1g
Yield:2725-81-7 98%
Reaction Conditions:
Stage #1:coumarin with sulfuric acid at 4; for 0.166667 h;
Stage #2: with guanidine nitrate
Steps:
Synthesis of 6-nitro-coumarin a
6-nitro-coumarin a was synthesied accroding to the lit (Wang et al. 2015). The concentrated sulphuric acid (29 mL) was added to coumarin (0.1 mol, 14.6 g) at 4 °C, and the mixture was stirred for 10 min. Then guanidine nitrate (0.1 mol, 12.2 g) was added slowly. The reaction was monitored by TLC. After completion of the reaction, the resulting mixture was slowly poured into crushed ice and the resulting solid was separated by filtration and washed successively with water. The product was dried to get white compound a in yield of 98%; HPLC>98.0%
References:
Ding, Yin-hao;Dong, Jing-jing;Feng, Bai-cheng;Hao, Shuang-hong;Jin, Yan;Wei, Yan [Natural Product Research,2020] Location in patent:supporting information
10242-15-6
27 suppliers
$45.00/50mg
2725-81-7
129 suppliers
$36.00/1g
