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ChemicalBook CAS DataBase List 6-Methylquinoline 1-oxide
4053-42-3

6-Methylquinoline 1-oxide synthesis

2synthesis methods
-

Yield:4053-42-3 96%

Reaction Conditions:

with dihydrogen peroxide in water; for 0.25 h;Sonication;

Steps:

3 Example 3Preparation of 6-methylquinoline nitrogen oxides:

In a 50 mL round-bottomed flask, 1.43 g of 6-methylquinoline, followed by hydrogen peroxide (35% by mass), 1.1 g, 5% were added.Mass fraction of perfluorosulfonic acid resin, 10 ml of water as a solvent, and the resulting mixture in an ultrasonic reactor at 30 W/20 KHzReact for 15 minutes under acoustic conditions. The resin catalyst in the reaction system is removed by filtration, the water in the reaction solvent is removed under reduced pressure, and finallyRecrystallization yielded 1.52 g of 6-methylquinoline nitrogen oxide in 96% yield.

References:

CN108003098,2018,A Location in patent:Paragraph 0052; 0053; 0054

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