6-METHOXY-2H-CHROMENE-3-CARBONITRILE synthesis
- Product Name:6-METHOXY-2H-CHROMENE-3-CARBONITRILE
- CAS Number:57543-71-2
- Molecular formula:C11H9NO2
- Molecular Weight:187.19
Yield:57543-71-2 91.3%
Reaction Conditions:
with 1,4-diaza-bicyclo[2.2.2]octane for 12 h;Reflux;
Steps:
General synthesis of compounds 13a-13d
General procedure: To a solution of 2-hydroxyl-3- methoxylbenzaldehyde (1g, 2-hydroxyl-4- methoxyl benzaldehyde, 2-hydroxyl-5- methoxylbenzaldehyde or 2-hydroxyl-4- methoxylbenzaldehyde) in acrylonitrile (2mL) DABCO (2eq.) was added. The sulotion was refluxed for 12h and loaded on a silica gel column after cold to room temperature and eluted with petroleum ether and acetone (10: 1 ~ 5: 1) to afford the product as a yellow solid.
References:
Zhang, Guoning;Liu, Shuainan;Tan, Wenjuan;Verma, Ruchi;Chen, Yuan;Sun, Deyang;Huan, Yi;Jiang, Qian;Wang, Xing;Wang, Na;Xu, Yang;Wong, Chiwai;Shen, Zhufang;Deng, Ruitang;Liu, Jinsong;Zhang, Yanqiao;Fang, Weishuo [European Journal of Medicinal Chemistry,2017,vol. 129,p. 303 - 309] Location in patent:supporting information
