6-chloro-N4-ethylpyrimidine-4,5-diamine synthesis
- Product Name:6-chloro-N4-ethylpyrimidine-4,5-diamine
- CAS Number:98140-03-5
- Molecular formula:C6H9ClN4
- Molecular Weight:172.62
Yield:98140-03-5 93%
Reaction Conditions:
with triethylamine in ethanol at 150; for 27 h;
Steps:
3 4.1.1. General procedure for the synthesis of N4-alkyl-4,5-diamino-6-chloropyrimidine 6-8
General procedure: A solution of 5-amino-4,6-dichloropyrimidine (5, 1.0 mmol),triethylamine (1.0 mmol), ethanol (4.3 mL), and the appropriateamine (2.5 mmol) was heated in a steel vial for the time specifiedfor each compound. After the removal of volatiles in vacuo, thecrude was purified as described for each compound.
References:
Lambertucci, Catia;Marucci, Gabriella;Dal Ben, Diego;Buccioni, Michela;Spinaci, Andrea;Kachler, Sonja;Klotz, Karl-Norbert;Volpini, Rosaria [European Journal of Medicinal Chemistry,2018,vol. 151,p. 199 - 213]
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