6-CHLORO-2-PIPERAZINO-1,3-BENZOTHIAZOLE synthesis

5synthesis methods

Product Name:6-CHLORO-2-PIPERAZINO-1,3-BENZOTHIAZOLE
CAS Number:153025-29-7
Molecular formula:C11H12ClN3S
Molecular Weight:253.75

110-85-0 Synthesis

110-85-0
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153025-29-7
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Yield:153025-29-7 1.33 g (100%)

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide;

Steps:

23.A 1-[1-{3-[4-(6-Chloro-benzothiazol-2-yl)-piperazin-1-yl]-2-hydroxy-propyl}-3-4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone

A. 6-Chloro-2-piperazin-1-yl-benzothiazole. To a stirred solution of 1.07 g (5.24 mmol) of 2,6-dichlorobenzothiazole in dry DMF (25 mL) was added 2.4 g of potassium carbonate (15.7 mmol) and 0.5 g of piperazine (5.8 mmol). The mixture was stirred at room temperature for 4 h. When the reaction was complete it was partitioned between EtOAc (150 mL) and water (50 mL) and separated. The aqueous layer was extracted with EtOAC (2*100 mL). The combined organic layers were then washed with water (2*25 mL), brine, dried over Na₂SO₄, and the solvent was removed under reduced pressure to give 1.33 g (100%) of desired product as a white solid. MS (electrospray): exact mass calculated for C₁₁H₁₂ClN₃S, 253.04; m/z found, 254.0 [M+H]⁺.

References:

US2003/69240,2003,A1

3622-23-9
218 suppliers
$14.00/1g