6-chloro-2-methoxynicotinaldehyde synthesis
- Product Name:6-chloro-2-methoxynicotinaldehyde
- CAS Number:95652-81-6
- Molecular formula:C7H6ClNO2
- Molecular Weight:171.58
55304-73-9
161 suppliers
$6.00/1g
124-41-4
698 suppliers
$12.00/25g
95652-81-6
88 suppliers
$23.00/100mg
Yield:95652-81-6 71.3%
Reaction Conditions:
with methanol at 55; for 3 h;
Steps:
184.A.A1
2,6-Dichloronicotinaldehyde (1 g, 5.68 mmol) was diluted with sodium methoxide (11.4 mL, 5.68 mmol) (solution in methanol) and heated to 55°C. After stirring for 3 hours, the reaction was loaded directly onto a silica gel column and eluted with 5% ethyl acetate/hexanes to 50% ethyl acetate/hexanes to yield 6-chloro-2- methoxynicotinaldehyde (0.695 g, 4.05 mmol, 71.3 % yield).
References:
WO2010/75200,2010,A1 Location in patent:Page/Page column 164
17228-64-7
312 suppliers
$6.00/5g
95652-81-6
88 suppliers
$23.00/100mg
55304-73-9
161 suppliers
$6.00/1g
95652-81-6
88 suppliers
$23.00/100mg
38496-18-3
375 suppliers
$6.00/1g
124-41-4
698 suppliers
$12.00/25g
95652-80-5
56 suppliers
$97.00/100mg
95652-81-6
88 suppliers
$23.00/100mg
67-56-1
752 suppliers
$9.00/25ml
55304-73-9
161 suppliers
$6.00/1g
95652-81-6
88 suppliers
$23.00/100mg