ChemicalBook CAS DataBase List 6-Chloro-2-hexanone

6-Chloro-2-hexanone synthesis

12synthesis methods

Product Name:6-Chloro-2-hexanone
CAS Number:10226-30-9
Molecular formula:C6H11ClO
Molecular Weight:134.6

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Yield:10226-30-9 89%

Reaction Conditions:

with 2-iodoxybenzoic acid;10-camphorsufonic acid in 1,4-dioxane;dichloromethane at 20;Inert atmosphere;

Steps:

General procedure

General procedure: Under nitrogen atmosphere, 1.1-1.5 mmol IBX and 10 to 20 mol% (±)-CSA monohydrate was added in round bottom flask already charged with magnetic bar and 2 mL DCM:1,4-Dioxane. Stirred the mixture for 10 minutes at room temperature and added the solution of alcohol dropwise for 5 minutes. Stirred the solution at room temperature till complete consumption of alcohol. Strip off the solvent and dilute the reaction mass with DCM. Filter the suspension through sintered funnel and wash the residue properly with DCM. This residue (white powdered solid, reduced part of IBX) was successfully used for preparation of IBX. Concentrate the filtrate on rotavapor and purify the product by column chromatography.

References:

Kumar, Kamlesh;Joshi, Penny;Rawat, Diwan S [Tetrahedron Letters,2021,vol. 81,art. no. 153298]