6-BROMO-TETRAL-1-ON synthesis
- Product Name:6-BROMO-TETRAL-1-ON
- CAS Number:66361-67-9
- Molecular formula:C10H9BrO
- Molecular Weight:225.08
3470-53-9
222 suppliers
$6.00/250mg
66361-67-9
168 suppliers
$50.00/100mg
Yield:66361-67-9 83%
Reaction Conditions:
Stage #1: 6-amino-1-tetralonewith hydrogen bromide;sodium nitrite in water; for 0.25 h;
Stage #2: with copper(I) bromide in water; for 0.25 h;
Steps:
6-bromo-3,4-dihydronaphthalen-1(2H)-one 3
To the solution of 2 (5 g and 31 mmol) in a mixture of hydrobromic acid (50 mL and47%) and water (50 mL) cooled by a brine/ice bath, a solution of sodium nitrite (2.5 gand 36 mmol) in water (20 mL) was added dropwise. The resulting mixture was stirredfor 15 min before a solution of cuprous bromide (5.14 g and 36 mmol) in hydrobromicacid (20 mL and 47%) was added dropwise. The resulting mixture was then stirred for15 min. The aqueous layers were washed with ethyl acetate (3 15 mL). The organic layerswere combined, dried over Na2SO4, filtered and evaporated. The resulting yellow oil waspuried by chromatography
References:
Chen, Baiyu;Fu, Wei;Li, Jianqi;Li, Wei;Li, Xinwei;Xie, Peng;Zhang, Junjie;Zhang, Wenbo;Zhu, Mengdan [Molecules,2022,vol. 27,# 7,art. no. 2173]
19936-14-2
69 suppliers
$43.00/100mg
66361-67-9
168 suppliers
$50.00/100mg
228256-58-4
8 suppliers
inquiry
66361-67-9
168 suppliers
$50.00/100mg
524-38-9
504 suppliers
$5.00/25g
35333-26-7
44 suppliers
$52.00/100mg
66361-67-9
168 suppliers
$50.00/100mg
3470-50-6
227 suppliers
$6.00/1g
66361-67-9
168 suppliers
$50.00/100mg