ChemicalBook CAS DataBase List 6,7-difluoro-1,2-dihydroquinoxalin-2-one

6,7-difluoro-1,2-dihydroquinoxalin-2-one synthesis

5synthesis methods

Product Name:6,7-difluoro-1,2-dihydroquinoxalin-2-one
CAS Number:137690-08-5
Molecular formula:C8H4F2N2O
Molecular Weight:182.13

76179-40-3 Synthesis

76179-40-3
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298-12-4 Synthesis

298-12-4
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6,7-difluoro-1,2-dihydroquinoxalin-2-one

137690-08-5
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Yield:137690-08-5 87.7%

Reaction Conditions:

with acetic acid in isopropyl alcohol at 50; for 18 h;

Steps:

Preparation of 6,7-difluoroquinoxalin-2(1H)-one (VIa-04)

Preparation of 6,7-difluoroquinoxalin-2(1H)-one (VIa-04) (0442) (0443) After addition of 1 ml of acetic acid, 3.00 g (21.1 mmol) of 4,5-difluorobenzene-1,2-diamine and 3.00 g (32.5 mmol) of glyokylic acid monohydrate in 100 ml of isopropanol are stirred at 50° C. for 18 h. (0444) After cooling, the solvent is then removed under reduced pressure. The residue is stirred with water and the dark-brown solid is filtered off with suction. (0445) This leaves 3.37 g (87.7% of theory, purity according to 1H-NMR 100%). (0446) 1H-NMR (D₆-DMSO) δ ppm: 12.54 (broad, 1H), 8.19 (s, 1H), 7.95-7.90 (m, 1H), 7.26-7.21 (m, 1H)

References:

US2016/227779,2016,A1 Location in patent:Paragraph 0442; 0443; 0444; 0445; 0446