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ChemicalBook CAS DataBase List 6(4-BROMOPHENYL)-3(2H)PYRIDAZINONE
50636-57-2

6(4-BROMOPHENYL)-3(2H)PYRIDAZINONE synthesis

8synthesis methods
36725-37-8 Synthesis
6-(4-BROMOPHENYL)-4 5-DIHYDRO-2H-PYRIDA&

36725-37-8
29 suppliers
$14.30/5g

-

Yield:50636-57-2 100%

Reaction Conditions:

with bromine in acetic acid at 20 - 100; for 1 h;

Steps:

66.B 6-(4-Bromo-phenyl)-2H-pyridazin-3-one

Example 66B 6-(4-Bromo-phenyl)-2H-pyridazin-3-one The product of example 66A (24.0 g, 94.5 mmol) was dissolved in HOAc (200 mL) and treated with bromine (Aldrich, 18.81 g, 104.5 mmol) in acetic acid (20 mL) at ambient temperature. The brown mixture was then warmed to 100° C. for 1 h, cooled down to ambient temperature and diluted with of water (200 mL) while stirring. The white precipitate was isolated by filtration and dried under vacuum overnight to provide the title compound (25.0 g, 100%). 1H NMR (300 MHz, CDCl3) δ 7.07 (d, J=10.2 Hz, 1H), 7.55-7.69 (m, 4H), 7.72 (d, J=9.8 Hz, 1H); MS (DCl/NH3) m/z 251 (M+H)+, 253 (M+H)+.

References:

US2005/101602,2005,A1 Location in patent:Page/Page column 42

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