5-(4-METHYL-2-NITRO-PHENYL)-FURAN-2-CARBOXYLIC ACID synthesis
1synthesis methods
- Product Name:5-(4-METHYL-2-NITRO-PHENYL)-FURAN-2-CARBOXYLIC ACID
- CAS Number:55377-91-8
- Molecular formula:C12H9NO5
- Molecular Weight:247.2
Yield:55377-91-8 45%
Reaction Conditions:
Stage #1: 4-methyl-2-nitroanilinewith hydrogenchloride;sodium nitrite
Stage #2: 2-furanoic acidwith copper(II) chloride dihydrate in water;acetone at 0 - 30;
References:
Gorak;Obushak;Matiichuk;Lytvyn [Russian Journal of Organic Chemistry,2009,vol. 45,# 4,p. 541 - 550] Location in patent:experimental part