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25593-82-2

5-Tetradecyn-1-ol synthesis

2synthesis methods
-

Yield:25593-82-2 62%

Reaction Conditions:

Stage #1: 5-hexyl-1-olwith n-butyllithium in tetrahydrofuran;N,N,N,N,N,N-hexamethylphosphoric triamide at -10 - 20; for 3 h;
Stage #2: 1-Iodooctane in tetrahydrofuran;N,N,N,N,N,N-hexamethylphosphoric triamide;

References:

Verniest, Guido;Boterberg, Stefaan;Colpaert, Jeroen;Van Thienen, Tinneke;Stevens, Christian V.;De Kimpe, Norbert [Synlett,2004,# 7,p. 1273 - 1275]