Yield:40929-48-4 87%

Reaction Conditions:

with thionyl chloride at 110; for 1 h;Inert atmosphere;

Steps:

1 Step 1 - Pyrimidine-5-carbonyl chloride

A solution of pyrimidine-5-carboxylic acid (500 mg, 4.03 mmol, CAS 4595-61- 3) in SOCl2 (10 mL) was stirred at 110 °C for 1 hour. On completion, the reaction mixture was concentrated in vacuo to give the title compound (500 mg, 87% yield) as a brown solid, which was used for next step directly.

References:

WO2020/264499,2020,A1 Location in patent:Paragraph 00920; 002973-002975