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ChemicalBook CAS DataBase List 5-PHENYL-N-VALERIC ACID METHYL ESTER
20620-59-1

5-PHENYL-N-VALERIC ACID METHYL ESTER synthesis

7synthesis methods
-

Yield: 66 %Chromat.

Reaction Conditions:

in methanol;diethyl ether at 0 - 20;

Steps:

4.3. General procedure for the oxidation of the long chainalcohol 3a-3h
General procedure: To the solution of the mixture in diethyl ether (5 mL) andmethanol (4 mL) in ice bath, a solution of trimethysilyldiazomethanein diethyl ether (2 mL, 2 M, 4 mmol) was added dropwisewhile stirring, and stirring for 2 h, then ice bath was removed andstirring overnight. Upon removal of residual solvents and trimethylsilylspecies, the product was obtained and the product wasdetected by GCeMS. The original spectra of GCeMS were given inthe Supplementary data.

References:

Yu, Dong-Fang;Xing, Ping;Jiang, Biao [Tetrahedron,2015,vol. 71,# 25,p. 4269 - 4273]

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