ChemicalBook CAS DataBase List 5-Iodo-2-methylbenzoic acid

5-Iodo-2-methylbenzoic acid synthesis

9synthesis methods

Product Name:5-Iodo-2-methylbenzoic acid
CAS Number:54811-38-0
Molecular formula:C8H7IO2
Molecular Weight:262.04

118-90-1 Synthesis

118-90-1
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$13.00/1g

54811-38-0
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$5.00/5g

Yield:54811-38-0 94.5%

Reaction Conditions:

with ammonium cerium (IV) nitrate;sulfuric acid;iodine;acetic acid at 40;Temperature;Reagent/catalyst;

Steps:

1 Example 1
500ml reaction flask, add solvent acetic acid (54.4g), concentrated sulfuric acid (16.3g), stir and mix well, Next add o-toluic acid (13.6 g, 0.1 mol), iodine (25.3 g, 0.06 mol) in succession.Niobium nitrite (28 g, 0.0001 mol) was directly passed through concentrated sulfuric acid-dried air. The reaction was maintained at a temperature of 40°C and TLC monitored the disappearance of the starting material. After the reaction is complete, 200 ml of water is added to the system. A large amount of solids precipitated out, which was filtered, washed with water and dried to obtain a solid. The reaction yield was 94.5%, and the HPLC purity was 99.3%. The NMR spectrum of 2-methyl-5-iodobenzoic acid is shown in Figure 1.

References:

Ningbo Renjian Chemical Pharmaceutical Co., Ltd.;Zheng Fei;Zhou Li;Gao Shengjun;Wang Weimin CN107652175, 2018, A Location in patent:Paragraph 0054-0098

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