5-Iodo-1H-pyrrole-2-carbaxaldehyde synthesis
- Product Name:5-Iodo-1H-pyrrole-2-carbaxaldehyde
- CAS Number:40566-13-0
- Molecular formula:C5H4INO
- Molecular Weight:221
![5H,10H-Dipyrrolo[1,2-a:1',2'-d]pyrazine-5,10-diamine, N5,N5,N10,N10-tetramethyl-](/CAS/20210111/GIF/64435-30-9.gif)
64435-30-9
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40566-13-0
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Yield:40566-13-0 65%
Reaction Conditions:
Stage #1: N5,N5,N10,N10-tetramethyl-5,10-dihydrodipyrrolo[1,2-a:1',2'-d]pyrazine-5,10-diaminewith n-butyllithium in tetrahydrofuran;pentane at -15 - 20; for 1.75 h;
Stage #2: with iodine in tetrahydrofuran;pentane at -75 - 20;
Stage #3: with water;sodium acetate for 5 h;Reflux;
References:
Bowie, Alfred L.;Trauner, Dirk [Journal of Organic Chemistry,2009,vol. 74,# 4,p. 1581 - 1586] Location in patent:experimental part
