5-hydroxybenzo[b]thiophene-2-carboxylic acid synthesis
- Product Name:5-hydroxybenzo[b]thiophene-2-carboxylic acid
- CAS Number:95094-87-4
- Molecular formula:C9H6O3S
- Molecular Weight:194.21
42056-20-2
0 suppliers
inquiry
95094-87-4
12 suppliers
inquiry
Yield:95094-87-4 35%
Reaction Conditions:
with iodine in tetrahydrofuran; for 26 h;Reflux;
Steps:
83 Synthesis of Compound 4
A stirred solution of compound 3 (38.6 g, 195.94 mmol) and iodine (62.5 g, 244.92 mmol) in dry THF was heated to reflux for 26 h. After removing almost of THF, the residue was poured into water. The pH was adjusted to 12 by progressively adding solid NaOH and the water phase was washed with EA for 3 times, then the water phase was acidified by conc.HCl to pH 2. The result precipitate was collected by filtration, washed by water, dried to give compound 4 (13.5 g, 35%) as light yellow solid.
References:
JP2015/214548,2015,A Location in patent:Paragraph 1384; 1388; 1389
20699-85-8
81 suppliers
$13.00/100mg
95094-87-4
12 suppliers
inquiry
6345-55-7
79 suppliers
$8.00/100mg
95094-87-4
12 suppliers
inquiry
98589-46-9
45 suppliers
$57.50/250mg
95094-87-4
12 suppliers
inquiry
27996-87-8
175 suppliers
$5.00/1g
95094-87-4
12 suppliers
inquiry