5-Chloropyrazolo[1,5-a]pyrimidine synthesis
- Product Name:5-Chloropyrazolo[1,5-a]pyrimidine
- CAS Number:29274-24-6
- Molecular formula:C6H4ClN3
- Molecular Weight:153.57
![5-Hydroxypyrazolo[1,5-a]pyrimidine](/CAS/GIF/29274-22-4.gif)
29274-22-4
145 suppliers
$9.00/100mg
29274-24-6
234 suppliers
$9.00/250mg
Yield:29274-24-6 88%
Reaction Conditions:
with trichlorophosphate in acetonitrile at 85; for 2 h;Large scale;
Steps:
2
n the second step, 1 kg of the compound C is dissolved in 2 kg of acetonitrile, and 400 g of phosphorus oxychloride is slowly added to the acetonitrile solution of the compound C under anhydrous oxygen-free and nitrogen-free protection, heated to 85 ° C, and refluxed for 2 hours. Clarification, the solvent was evaporated under reduced pressure to give a yellow solid, and 1 kg of water was slowly added to the yellow solid to remove a small amount of residual thionyl chloride, and filtered to obtain 1 kg of a yellow solid compound D in a yield of 88%
References:
Shanghai Lingkai Pharmaceutical Technology Co., Ltd.;Lu Qian;Kuang Yi;Cui Xiaozhan CN109251205, 2019, A Location in patent:Paragraph 0025; 0026; 0029
29274-22-4
145 suppliers
$9.00/100mg
29274-24-6
234 suppliers
$9.00/250mg
![5-BROMOPYRAZOLO[1,5-A]PYRIMIDINE](/CAS2/GIF/1159981-95-9.gif)
1159981-95-9
69 suppliers
$28.00/100mg
29274-24-6
234 suppliers
$9.00/250mg