天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

1174906-84-3

5-CHLORO-2-METHYLTHIOBENZAMIDE synthesis

1synthesis methods
5-chloro-2-MethylbenzaMide

1028252-11-0
13 suppliers
inquiry

5-CHLORO-2-METHYLTHIOBENZAMIDE

1174906-84-3
7 suppliers
$60.00/1g

-

Yield:-

Reaction Conditions:

with Lawessons reagent in tetrahydrofuran at 23; for 1 h;

Steps:

4.2. Preparation of thioamides 2. General procedure

General procedure: Amides (1 mmol) and Lawesson's reagent (490 mg, 1.2 mmol) were added to dry THF (15 mL). The reaction mixture was stirred at room temperature for 1 h, or heated under reflux for 5 h in the case of the 4-nitro derivative. The solvent was evaporated under reduced pressure and the residue was partitioned between aq NaHCO3 (25 mL) and ethyl acetate (25 mL). The organic solvent was separated and dried over anhydrous MgSO4. The crude product was further purified by silica gel flash chromatography, using hexane-ethyl acetate (4:1), to yield the corresponding thioamides as yellow solids (42-60%). 4-Nitrothioamide (2ff),38 4-cyanothiobenzamide (2gg)39 and 3-cyanothiobenzamide (2hh),40 3-methoxythiobenzamide (2ii)41 have been previously reported.

References:

Mayhoub, Abdelrahman S.;Marler, Laura;Kondratyuk, Tamara P.;Park, Eun-Jung;Pezzuto, John M.;Cushman, Mark [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 1,p. 510 - 520] Location in patent:experimental part