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ChemicalBook CAS DataBase List 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER
350597-49-8

5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C
1.2: 86 percent / DABCO / 3 h / 45 °C
2.1: 95 percent Chromat. / NH4OAc / tetrahydrofuran / 6 h / Heating

References:

Marcoux;Marcotte;Wu;Dormer;Davies;Hughes;Reider [Journal of Organic Chemistry,2001,vol. 66,# 12,p. 4194 - 4199]

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