5-Chloro-2-hydroxybenzoic acid synthesis
- Product Name:5-Chloro-2-hydroxybenzoic acid
- CAS Number:321-14-2
- Molecular formula:C7H5ClO3
- Molecular Weight:172.57
69-72-7
1286 suppliers
$5.00/10g
321-14-2
382 suppliers
$15.00/25g
Yield:321-14-2 92%
Reaction Conditions:
Stage #1:salicylic acid with sulfuric acid in acetonitrile at 20; for 0.0833333 h;
Stage #2: with N-chloro-succinimide in acetonitrile at 20; for 2.5 h;regioselective reaction;
Steps:
Representative procedure for the preparation of compound 1a
General procedure: To a solution of 4-fluoro-2-hydroxybenzoic acid (780.6 mg, 5 mmol) in MeCN (10 mL) was added con. H2SO4 (285 μL, 1.05 equiv.) at room temperature, the mixture was stirred for 5 min. Then, NBS (934.4 mg, 1.05 equiv.) was added to the mixture. The reaction was monitored using TLC analysis. The mixture was evaporated to dryness and MeCN (1 mL) was added to the flask. The mixture was stirred for 10 min and filtered. The filter cake was washed by water and dried to obtain the product as a white solid; yield: 85% (0.99 g).
References:
Wu, Yong-Qi;Lu, Hai-Jia;Zhao, Wen-Ting;Zhao, Hong-Yi;Lin, Zi-Yun;Zhang, Dong-Feng;Huang, Hai-Hong [Synthetic Communications,2020,vol. 50,# 6,p. 813 - 822] Location in patent:supporting information
124-38-9
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106-48-9
501 suppliers
$10.00/5 g
321-14-2
382 suppliers
$15.00/25g
535-80-8
414 suppliers
$5.00/5g
321-14-2
382 suppliers
$15.00/25g
69-72-7
1286 suppliers
$5.00/10g
321-14-2
382 suppliers
$15.00/25g
1829-32-9
149 suppliers
$55.00/5g
106-48-9
501 suppliers
$10.00/5 g
321-14-2
382 suppliers
$15.00/25g