5-Bromothiophenesulfonyl chloride synthesis
- Product Name:5-Bromothiophenesulfonyl chloride
- CAS Number:55854-46-1
- Molecular formula:C4H2BrClO2S2
- Molecular Weight:261.54
1003-09-4
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55854-46-1
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Yield: 77.3%
Reaction Conditions:
with chlorosulfonic acid in dichloromethane at -78 - 20; for 1 h;
Steps:
1 Step-1:
To a solution of 2-bromothiophene (5.0 g, 30.566 mmol) in DCM (50 ml_) was added chlorosulfuric acid (17.86 g, 153.34 mmol) at -78 °C and allowed to stir at room temperature for 1 h. After completion of the reaction as indicated by TLC, the reaction mixture was poured into water (200 mL) and extracted with DCM (2 x 200 mL). The combined organic layer was dried over Na2SO4 and evaporated under vacuum to give Int- B-2.15-A1 (6.2 g, 77.30 %). It was used immediately for the next step without analysis.
References:
OXFORD DRUG DESIGN LIMITED WO2021/123237, 2021, A1 Location in patent:Page/Page column 217
3141-27-3
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55854-46-1
237 suppliers
$6.00/1g