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ChemicalBook CAS DataBase List 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione
4956-05-2

6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione synthesis

1synthesis methods
2H- [1, 2,4] triazin-3,5-dione (50 g, 442 mmol) is placed in 60 ml of bromine in 800 ml of water at 60°C for 10 h. The reaction medium is then run slowly onto an aqueous ammonia solution until pH = 5. It is then extracted with ethyl acetate and the organic phases are dried over MgS04. After filtration and concentration to dryness, 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione is isolated as a white solid (79.2 g, yield = 93 percent).
-

Yield: 93%

Reaction Conditions:

with water;bromine at 60; for 10 h;

Steps:

2.i
1) 6-Bromo-2H-f 1, 2, 41tri azi ne-3, 5-d i one (2i); 2H- [1, 2,4] triazin-3,5-dione (50 g, 442 mmol) is placed in the presence of 60 ml of bromine in 800 ml of water at 60°C for 10 h. The reaction medium is then run slowly onto a solution of aqueous ammonia until pH = 5. It is then extracted with ethyl acetate and the organic phases are dried over MgS04. After filtration and concentration to dryness, 2i is isolated in the form of a white solid (79.2 g, yield = 93%). TLC Merck silica gel 60 F 254, CH2CI2-MeOH : 90-10, Rf = 0.32.

References:

PIERRE FABRE MEDICAMENT WO2005/80354, 2005, A1 Location in patent:Page/Page column 19

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