5-BROMO-3-FLUORO-PYRIDINE-2-CARBONITRILE synthesis
- Product Name:5-BROMO-3-FLUORO-PYRIDINE-2-CARBONITRILE
- CAS Number:886373-28-0
- Molecular formula:C6H2BrFN2
- Molecular Weight:201
669066-90-4
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$150.00/1g
886373-28-0
167 suppliers
$8.00/250mg
Yield:886373-28-0 73%
Reaction Conditions:
Stage #1:5-bromo-3-fluoro-pyridine-2-carboxylic acid amide with sodium chloride;trichlorophosphate in dichloromethaneHeating / reflux;
Stage #2: with sodium hydrogencarbonate in dichloromethane;water at 20;
Steps:
Stir amixture of S-bromo-S-fluoro-pyridine^-carboxylic acid amide (0.375 mg, 1.71 mmol) and NaCl (0.120 g, 2.05 mmol) in CH2Cl2 (20 ml). After 15 minutes, addPOCl3 (0.795 ml, 8.55 mmol) and reflux the mixture overnight. Cool the mixture to room temperature, and dilute with CH2Cl2; wash with saturated NaHCO3 solution, dry(MgSO^. Purify the crude product using silica chromatography (0-50% EtOAc/Hexane) to produce 0.25 g (73% yield) of 5-bromo-2-cyano-3- fluoro-pyridine.
References:
ELI LILLY AND COMPANY WO2007/87488, 2007, A2 Location in patent:Page/Page column 23
573675-25-9
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$13.00/5g
886373-28-0
167 suppliers
$8.00/250mg
573675-25-9
276 suppliers
$13.00/5g
886373-28-0
167 suppliers
$8.00/250mg
1160936-51-5
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15862-34-7
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$10.00/5g
886373-28-0
167 suppliers
$8.00/250mg
15862-37-0
238 suppliers
$6.00/1g
886373-28-0
167 suppliers
$8.00/250mg