5-bromo-2-phenylpyrimidine-4-carboxylic acid synthesis
1synthesis methods
- Product Name:5-bromo-2-phenylpyrimidine-4-carboxylic acid
- CAS Number:179260-95-8
- Molecular formula:C11H7BrN2O2
- Molecular Weight:279.09
Yield:179260-95-8 44%
Reaction Conditions:
in water;
Steps:
240.A A.
A. 2-Phenyl-5-bromo-4-pyrimidine carboxylic acid To a solution of mucobromic acid (16 g, 62 mmol) in 800 ml of water was added benzamidine hydrochloride hydrate (26 g, 166 mmol) and Triton B (100 ml, 40% in water). The solution was stirred 23 hours, filtered of a small amount of dark solid, and acidified with concentrated HCl. The gummy precipitate was filtered and recrystallized from 4:1 ethanol:water to afford 5.87 g (34%) of Compound A as a brown crystalline solid. Concentration of the mother liquor afforded an additional 1.72 g (44% total yield).
References:
US6011029,2000,A