5-Bromo-2-chloro-4-methylpyrimidine synthesis
- Product Name:5-Bromo-2-chloro-4-methylpyrimidine
- CAS Number:633328-95-7
- Molecular formula:C5H4BrClN2
- Molecular Weight:207.46
36082-50-5
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$5.00/1g
75-16-1
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$12.00/10ml
633328-95-7
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$12.00/250mg
Yield: 60%
Reaction Conditions:
with iron(III)-acetylacetonate in tetrahydrofuran;diethyl ether at 0; for 25 h;
Steps:
16.1 Step I: 5-bromo-2-chloro-4-methyl-pyrimidine
A mixture of 5-Bromo 2,4-dichloropyrimidine (0.4 g) and lron(lll)acetylacetonate (0.062 g) in Tetrahydrofuran (10 mL) was cooled to 0 °C. Methyl magnessium bromide (3 M solution in Diethylether) (0.76 mL) was added dropwise and the mixture stirred for 2 h. Saturated Aminonium Chloride solution was added and the mixture extracted with Ethyl acetate (2 X 20 mL). The organic extracts were dried over anhydrous Sodium sulphate and evaporated under reduced pressure to get a residue which was purified by Silica gel flash column chromatography eluting with a gradient of Ethyl acetate and n-heptane to afford the desired product (0.220 g, 60 %) as a white solid. I H NMR (300 MHz, CDCI3) 6 8.52 (5, 1 H), 2.57 (5, 3H).
References:
BASF SE;SAMBASIVAN, Sunderraman;NARINE, Arun;CHAUDHURI, Rupsha;VALLINAYAGAM, Ramakrishnan;VYAS, Devendra;ADISECHAN, Ashokkumar;DATTA, Gopal Krishna WO2018/108671, 2018, A1 Location in patent:Page/Page column 169; 170
17321-93-6
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$8.00/250mg
633328-95-7
98 suppliers
$12.00/250mg