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ChemicalBook CAS DataBase List 5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE
433683-47-7

5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE synthesis

5synthesis methods
-

Yield:433683-47-7 296 mg

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 80; for 2 h;

Steps:

3.B B) 5-bromo-2-(2,2,2-trifluoroethoxy)pyrimidine

A mixture of 5-bromopyrimidin-2-ol (500 mg), 2,2,2-trifluoroethyl trifluoromethanesulfonate (796 mg), cesium carbonate (1397 mg) and DMF (5 mL) was stirred at 80° C. for 2 hr.
Water was added to the mixture and the mixture was extracted with ethyl acetate.
The organic layer was separated, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure.
The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (296 mg).
1H NMR (300 MHz, CDCl3) 54.79 (2H, q, J=8.2 Hz), 8.58 (2H, s).

References:

US2020/39957,2020,A1 Location in patent:Paragraph 0641

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