5-BENZYLOXYINDOLE-3-ACETAMIDE synthesis

6synthesis methods

Product Name:5-BENZYLOXYINDOLE-3-ACETAMIDE
CAS Number:5933-28-8
Molecular formula:C17H16N2O2
Molecular Weight:280.32

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Yield:-

Reaction Conditions:

in ethanol;water;

Steps:

57 Preparation of 5-Benzyloxyindole-3-acetamide

EXAMPLE 57 Preparation of 5-Benzyloxyindole-3-acetamide A solution of 8.41 g (0.03 mol) of 5-benzyloxygramine, 7.5 g (0.15 mol) of sodium cyanide, 120 ml of ethanol and 30 ml of water was refluxed for 90 hours. The solution, which contained some precipitate, was diluted with 200 ml of water and cooled in the refrigerator. The crystalline material which separated was washed thoroughly with water and dried, giving 4.40 g (52.3%) of a slightly brown sticky tan powder, m.p. 137°-140° C. Recrystallization from methanol/benzene gave small needles, m.p. 156°-158° C., of 5-benzyloxyindole-3-acetamide. IR (KB) 3400, 3290, 3180, 1645, 1610, 1580, 1485, 1450, 1275, 1210, 1200 and 795 cm^-1.

References:

US4540564,1985,A US4824850,1989,A

1453-97-0
58 suppliers
$172.00/1g