ChemicalBook CAS DataBase List 5-Benzyloxy-4-methoxy-2-nitrobenzaldehyde

5-Benzyloxy-4-methoxy-2-nitrobenzaldehyde synthesis

8synthesis methods

Product Name:5-Benzyloxy-4-methoxy-2-nitrobenzaldehyde
CAS Number:58662-50-3
Molecular formula:C15H13NO5
Molecular Weight:287.27

6346-05-0 Synthesis

6346-05-0
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5-Benzyloxy-4-methoxy-2-nitrobenzaldehyde

58662-50-3
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Yield:58662-50-3 94.9%

Reaction Conditions:

with HNO₃ at 10 - 15; for 3 h;

Steps:

1.B 2-aldehyde-4-benzyloxy-5-methoxy nitrobenzene (A-2)

Intermediate A-2 (40.0 g, 0.165 mol) was added under ice-cooling,Slowly added to 160mL concentrated nitric acid,After completion of the reaction, the reaction was continued at 10 ° C to 15 ° C for 180 min.After completion of the reaction, the reaction solution was poured into ice water,There is a yellow precipitate generated, filtered and then the filter cake into the water with 10% NaOH mediation PH = 7,And then filter with a large number of water detergent cake to the lotion to obtain the filtrate as colorless,Dried to give 45 g of a pale yellow solid in 94.9% yield.

References:

CN106543162,2017,A Location in patent:Paragraph 0211-0212