5-AMINOMETHYL-PYRROLIDIN-2-ONE synthesis
- Product Name:5-AMINOMETHYL-PYRROLIDIN-2-ONE
- CAS Number:154148-69-3
- Molecular formula:C5H10N2O
- Molecular Weight:114.15
113466-82-3
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Yield: 15%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethanol at 20; under 760.051 Torr; for 5 h;
Steps:
3.3 Step 3: Preparation of 5-(aminomethyl) pyrrolidin-2-one (4)
To a solution of compound 3 (1.97 g) in EtOH (55 mL) was added Pd/C (10% wt, 400 mg). The resulting mixture was stirred at rt under 1 atm of H2 atmosphere for 5 h. The mixture was filtered and the filtrate was concentrated and purified to give compound 4 as a yellow oil (620 mg, yield 15%).
References:
SYNBLIA THERAPEUTICS, INC.;XIE, Yinong;BABISS, Lee, E. WO2019/89422, 2019, A1 Location in patent:Paragraph 0138
89717-54-4
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591-80-0
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