ChemicalBook CAS DataBase List 5,7-DICHLORO-4-HYDROXYQUINOLINE

5,7-DICHLORO-4-HYDROXYQUINOLINE synthesis

9synthesis methods

Product Name:5,7-DICHLORO-4-HYDROXYQUINOLINE
CAS Number:21873-52-9
Molecular formula:C9H5Cl2NO
Molecular Weight:214.05

93514-82-0 Synthesis

ETHYL 5,7-DICHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLATE

93514-82-0
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21873-52-9
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171850-30-9 Synthesis

5,7-DICHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

171850-30-9
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$87.00/1g

Yield:21873-52-9 78%

Reaction Conditions:

with sulfuric acid

Steps:

3 Example 3

Example 3 (Manufacture of 5,7-Dichloro-4-hydroxyquinoline) 5,7-Dichloro-3-ethoxycarbonyl-4-hydroxyquinoline (114.4 g; 0.4 mole) and 343.2 g of 70% sulfuric acid were charged in a 1,000 ml four-necked flask equipped with stirrer, thermometer and distilling tube and the mixture was heated at 150° C. with stirring. Reaction was continued by heating up to 165° C. during three hours together with evaporation of the by-produced ethanol outside the reaction system. The reaction product was analyzed by liquid chromatography whereupon and it was found that the starting 5,7-dichloro-3-ethoxycarbonyl-4-hydroxy-quinoline disappeared and that 5,7-dichloro-3-carboxy-4-hydroxyquinoline in 22% yield and 5,7-dichloro-4-hydroxyquinoline in 78% yield were produced.

References:

US5731440,1998,A