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13177-71-4

5,6-dihydrofuro[3,2-d]pyridazine-4,7-dione synthesis

4synthesis methods
52900-79-5 Synthesis
2,3-furandicarboxylic acid dimethyl ester

52900-79-5
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5,6-dihydrofuro[3,2-d]pyridazine-4,7-dione

13177-71-4
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Yield:13177-71-4 70%

Reaction Conditions:

with hydrazine hydrate in ethanol;water; for 6 h;Reflux;

References:

Miller-Moslin, Karen;Peukert, Stefan;Jain, Rishi K.;McEwan, Michael A.;Karki, Rajesh;Llamas, Luis;Yusuff, Naeem;He, Feng;Li, Yanhong;Sun, Yingchuan;Dai, Miao;Perez, Lawrence;Michael, Walter;Sheng, Tao;Lei, Huangshu;Zhang, Rui;Williams, Juliet;Bourret, Aaron;Ramamurthy, Arun;Yuan, Jing;Guo, Ribo;Matsumoto, Melissa;Vattay, Anthony;Maniara, Wieslawa;Amaral, Adam;Dorsch, Marion;Kelleher III, Joseph F. [Journal of Medicinal Chemistry,2009,vol. 52,# 13,p. 3954 - 3968] Location in patent:experimental part