ChemicalBook CAS DataBase List 4-Vinylbenzoic acid

4-Vinylbenzoic acid synthesis

11synthesis methods

Product Name:4-Vinylbenzoic acid
CAS Number:1075-49-6
Molecular formula:C9H8O2
Molecular Weight:148.16

2039-82-9 Synthesis

2039-82-9
272 suppliers
$10.00/1g

124-38-9
130 suppliers
$214.00/14L

1075-49-6
295 suppliers
$17.00/1g

Yield:1075-49-6 99%

Reaction Conditions:

with tris-(dibenzylideneacetone)dipalladium⁽⁰⁾;phenylsilane;triethylamine;DPEPhos in 1-methyl-pyrrolidin-2-one at 60; under 760.051 Torr; for 18 h;

Steps:

13

0.3 mmol of 4-bromostyrene, 0.006 mmol of bis(dibenzylideneacetone) palladium, 0.0075 mmol of bis(2-diphenylphosphinophenyl) ether, 0.3 mmol of triethylamine, 0.6 mmol of benzene Silane and 2 mL of N-methylpyrrolidone were added to the reaction tube, and then the reaction tube was evacuated and carbon dioxide was introduced into the reaction tube until the pressure in the reaction tube was 1 atm, and the reaction was stirred at 60 °C for 18 h at a stirring rate of 600 rpm, and then heating and stirring were stopped. Naturally Cool to room temperature, add 2 mol/L hydrochloric acid solution for acidification, extract 3 times with ethyl acetate, combine the organic phases, dry with anhydrous sodium sulfate, filter, concentrate under reduced pressure, and then purify by column chromatography. The eluent of the precipitation was composed of petroleum ether and ethyl acetate according to the volume ratio of 5:1 to obtain an aromatic carboxylic acid compound (yield 99%).

References:

CN113801015,2021,A Location in patent:Paragraph 0111-0118

124-38-9
130 suppliers
$214.00/14L

676593-23-0 Synthesis