ChemicalBook CAS DataBase List 4-TRIMETHYLSILYL-3-BUTYN-1-OL

4-TRIMETHYLSILYL-3-BUTYN-1-OL synthesis

10synthesis methods

Product Name:4-TRIMETHYLSILYL-3-BUTYN-1-OL
CAS Number:2117-12-6
Molecular formula:C7H14OSi
Molecular Weight:142.27

925-90-6 Synthesis

925-90-6
353 suppliers
$12.00/5ml

927-74-2 Synthesis

927-74-2
427 suppliers
$6.00/5g

2117-12-6
72 suppliers
$7.00/1g

Yield:-

Reaction Conditions:

with sulfuric acid in tetrahydrofuran;chloro-trimethyl-silane

Steps:

8.1 Step 1--Preparation of 4-trimethylsilyl-3-butyne-1-ol
Step 1--Preparation of 4-trimethylsilyl-3-butyne-1-ol A solution of 2 mol of ethyl magnesium bromide (2.0 molar solution in tetrahydrofuran) is cooled in an ice bath and a solution of 50.5 g of 3-butyn-1-ol (0.72 mol) in 50 ml of tetrahydrofuran is slowly added. After addition is complete, the mixture was allowed to warm to room temperature and was stirred overnight. The mixture was then cooled in an ice bath and 254 ml (2 mol) of chlorotrimethylsilane was slowly added. This mixture was heated under reflux for two hours and then cooled to 20° C. and 800 ml of 1.4 M aqueous sulfuric acid were added. The mixture was extracted with diethyl ether and the ether solution was dried and concentrated under vacuum. The residue was distilled to yield 72.8 g of 4-trimethylsilyl-3-butyne-1-ol, bp 43° -48° C. at 1 mm Hg.

References:

Warner-Lambert Company US4929734, 1990, A