4-(Trifluoromethyl)formanilide synthesis

13synthesis methods

Product Name:4-(Trifluoromethyl)formanilide
CAS Number:74702-40-2
Molecular formula:C8H6F3NO
Molecular Weight:189.13

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201230-82-2 Synthesis

201230-82-2
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74702-40-2
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Yield:74702-40-2 96 %Chromat.

Reaction Conditions:

with sodium tertiary butoxide in N,N-dimethyl acetamide at 100; under 1500.15 Torr; for 12 h;Autoclave;Pressure;

Steps:

45; 46 The preparation of p-trifluoromethylformanilide B19 is shown in schematic diagram 27 of its synthetic route.

In a glove box, add p-trifluoromethylaniline (10.0 mmol), tBuONa (10.0 mmol) and DMAc (10.0 mL) to a dry reaction vial with a magnetic stir bar,The reaction vial was placed in an autoclave, and after the CO gas was replaced three times in the autoclave, CO (2 bar) was charged. After the reaction was uniformly stirred at room temperature, the autoclave was placed in a preheated oil bath, and the reaction was carried out at 100 °C for 12 h. The reaction was stopped, and the column chromatography separation yield was 96%.

References:

CN115043750,2022,A Location in patent:Paragraph 0246-0261

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