ChemicalBook CAS DataBase List 4-TRIFLUOROMETHYL DIPHENYL SULFIDE

4-TRIFLUOROMETHYL DIPHENYL SULFIDE synthesis

11synthesis methods

Product Name:4-TRIFLUOROMETHYL DIPHENYL SULFIDE
CAS Number:53451-90-4
Molecular formula:C13H9F3S
Molecular Weight:254.27

128796-39-4 Synthesis

128796-39-4
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108-98-5
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Yield: 95%

Reaction Conditions:

with copper diacetate;triethylamine in dichloromethane at 0 - 5; for 4 h;Sonication;Green chemistry;

Steps:

General procedure: Naphthylboronic acid (0.25 g, 1.5 mmol) was added with 0.094 g of phenol (1.0 mmol) to 15 mL of DCM. Copper(II) acetate (0.36 g, 2.0 mmol) was then added along with triethylamine (0.5g, 5.0 mmol), and the dismembrator horn placed in the reaction vessel. The sonicator was set to 55 watts and the reaction was allowed to proceed for 4 hours (1 minute pulse with a 3 second rest). Post reaction, the product was isolated by column chromatography. Product yields were determined by weight and purity was confirmed by GC/MS and NMR.

References:

Musolino, Bryan J.;Kabalka, George W. [Heterocycles,2015,vol. 90,# 1,p. 271 - 297]

108-98-5
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98-56-6 Synthesis