4-(TRIFLUOROMETHYL)-1H-INDOLE synthesis
- Product Name:4-(TRIFLUOROMETHYL)-1H-INDOLE
- CAS Number:128562-95-8
- Molecular formula:C9H6F3N
- Molecular Weight:185.15
![EthenaMine, N,N-diMethyl-2-[2-nitro-6-(trifluoroMethyl)phenyl]-, (1E)-](/CAS/20150408/GIF/905274-06-8.gif)
905274-06-8
3 suppliers
inquiry
128562-95-8
110 suppliers
$27.00/100mg
Yield: 100%
Reaction Conditions:
with iron;acetic acidHeating / reflux;
Steps:
1.2
[0116] Step 2. 4-Trifluoromethyl-lH-indole[0117] To a solution of dimethyl-[2-(2-nitro-6-trifluoromethyl-phenyl)-vinyl]-amine (6.3 g, 24 mmol) in acetic acid (150 mL) was added iron powder (4.3 g, 77 mmol). The reaction was heated to reflux overnight under nitrogen. Upon cooling, the reaction mixture was diluted with 2.0 M HCl and the aqueous phase was extracted with ethyl acetate. The organic layer was neutralized with a saturated solution of potassium carbonate and extracted. Washed
References:
WYETH WO2008/60998, 2008, A1 Location in patent:Page/Page column 35-36
6656-49-1
169 suppliers
$6.00/1g
128562-95-8
110 suppliers
$27.00/100mg