4-tert-Butylphenyl-acetonitrile synthesis
- Product Name:4-tert-Butylphenyl-acetonitrile
- CAS Number:3288-99-1
- Molecular formula:C12H15N
- Molecular Weight:173.25
18880-00-7
213 suppliers
$9.00/5g
3288-99-1
234 suppliers
$15.00/5g
Yield:3288-99-1 99%
Steps:
1 EXAMPLE 1
EXAMPLE 1 This Example illustrates the preparation of 4-[3-(p- t -butylphenyl)- cis -cyclobutylmethyl]-2,6- cis -dimethylmorpholine (Compound No.3.1 in Table 1). A mixture of p- t -butylbenzyl bromide (20.44 g, 0.09 mol) and potassium cyanide (11.72 g, 0.18 ml) in a saturated solution of 18-crown-6 (50 ml) was refluxed at 80°C for 5 hours. After cooling to room temperature the solution was poured into water, extracted with dichloromethane and dried over anhydrous sodium sulphate. Removal of the solvent gave a yellow liquid which was purified by column chromatography (silica eluted with petroleum ether/ethyl acetate 9:1) to give p- t -butylbenzyl cyanide (15.4 g, 99%).
References:
EP253501,1990,A3
3972-56-3
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105-56-6
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$10.00/5ml
3288-99-1
234 suppliers
$15.00/5g
3972-65-4
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$8.00/10g
105-34-0
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$5.00/25g
3288-99-1
234 suppliers
$15.00/5g
13361-30-3
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$8.00/25g
35779-04-5
195 suppliers
$6.00/1g
3288-99-1
234 suppliers
$15.00/5g
