(4-propoxyphenyl)methanol synthesis

7synthesis methods

Product Name:(4-propoxyphenyl)methanol
CAS Number:90925-43-2
Molecular formula:C10H14O2
Molecular Weight:166.22

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Yield:90925-43-2 87%

Reaction Conditions:

with methanol;sodium tetrahydroborate at 20; for 1 h;Inert atmosphere;

Steps:

Synthetic procedure 2: reduction of the aldehyde

General procedure: NaBH₄ (1.1 mmol) was added to the alkoxy benzyl aldehyde (1.0 mmol) in methanol (5.0 mL) under nitrogen atmosphere. The reaction was stirred for 1 h at room temperature. The reaction mixture was concentrated under reduced pressure and water (20 mL) was added. The mixture was extracted with ethyl acetate (3×20 mL). The combined organic layers were dried with MgSO₄, filtered and the solvent was evaporated under reduced pressure.

References:

Eleftheriadis, Nikolaos;Thee, Stephanie;Te Biesebeek, Johan;Van Der Wouden, Petra;Baas, Bert-Jan;Dekker, Frank J. [European Journal of Medicinal Chemistry,2015,vol. 94,p. 265 - 275]