ChemicalBook CAS DataBase List 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE

4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE synthesis

5synthesis methods

Product Name:4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE
CAS Number:23239-75-0
Molecular formula:C12H18ClN
Molecular Weight:211.73

14548-46-0
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4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE

23239-75-0
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Yield: 99%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol;1,2-dichloro-ethane at 45; for 4.5 h;chemoselective reaction;Reagent/catalyst;Time;Pressure;Temperature;

Steps:

4.2. A typical procedure for preparation of 4-substituted piperidine hydrochlorides
General procedure: A suspension of 5a (366mg, 2.0mmol), 10% Pd-C (183mg, 50wt%), and ClCH₂CHCl₂ (320mg, 2.4mmol) in MeOH (30mL) was hydrogenated on an atmospheric pressure hydrogenator (or balloon) at 45°C until the absorption of hydrogen ceased (4.5h). After the Pd-C catalyst was filtered off, the solvent was removed on a rotavapor. The residue was diluted with diethyl ether (10mL) to give the desired product 1a·HCl (419mg, 99%) as a white crystal. The product was collected simply by a filtration and usually was pure enough for any analytical purposes.

References:

Cheng, Chuanjie;Wang, Bo;Liu, Nan;Chen, Wenwen;Wang, Xinyan;Hu, Yuefei [Tetrahedron,2014,vol. 70,# 4,p. 930 - 935]